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Novel Antibiotics

HAARBI

       Infect Control

 
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Mitteilung für Studierende

Kursmitteilungen und -unterlagen

 

 

Kontakt

Prof. Dr. Tanja Schneider

Pharmazeutische Mikrobiologie

Meckenheimer Allee 168 

53115 Bonn

Tel.: +49(0)228-73-5688/5266 

E-Mail: tschneider (at) uni-bonn.de

 

Sekretariat (8:30 Uhr bis 12:30 Uhr)

Karina Boltersdorf

Tel.: +49(0)228 73 7941

Fax: +49 (0)228-73-5267

E-Mail: kbolters (at) uni-bonn.de

 
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Publications

2015 - date

 

  • Eibach, D., M. Nagel, B. Hogan, C. Azuure, R. Krumkamp, D. Dekker, M. Gajdiss, M. Brunke, N. Sarpong, and E. Owusu-Dabo. 2017. Nasal Carriage of Staphylococcus aureus among children in the Ashanti region of Ghana.
    PLoS One. 12(1):e0170320
  • Wilmes, M., K. Meier, A. Schiefer, M. Josten, C.F. Otten, A. Klöckner, B. Henrichfreise, W. Vollmer, A. Hörauf, and K. Pfarr. 2017. AmiD is a novel peptidoglycan amidase in Wolbachia endosymbionts of Drosophila melanogaster.
    Front Cell Infect Microbiol. 7:353
  • Müller, A. , A. Klöckner, T. Schneider. 2017. Targeting a cell wall biosynthesis hot spot.
    Nat Prod Rep. 34(7):909-932
  • Nair, D.R., J. Chen, J.M.Monteiro, M. Josten, M.G. Pinho, H.-G. Sahl, J. Wu, and A. Cheung. 2017. A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.
    J Antibiot (Tokyo). Epub ahead of print
  • Böhringer, N., K.M. Fisch, D. Schillo, R. Bara, C. Hertzer, F. Grein, J.H. Eisenbarth, F. Kaligis, T. Schneider, H. Wägele, G.M. König, T.F. Schäberle. 2017. Antimicrobial potential of bacteria associated with marine sea slugs from north Sulawesi, Indonesia.
    Front Microbiol. 8:1092
  • Hufendiek, P., S.S.M. Stölben, S. Kehraus, N. Merten, H. Harms, M. Crüsemann, I. Arslan, M. Gütschow, T. Schneider, G.M. König. 2017. Biosynthetic studies on Acetosellin and structure elucidation of a new acetosellin derivative.
    Planta Med. 83(12-13):1044-1052
  • Schuster, D., J. Rickmeyer, M. Gajdiss, T. Thye, S. Lorenzen, M. Reif, M. Josten, C. Szekat, L.D.R. Melo, R.M. Schmithausen, Fl. Liégeois, H.-G. Sahl, J.-P. J. Gonzalez, M. Nagel, G. Bierbaum. 2017. Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape.
    Int J Med Microbiol. 307(1):57-63
  • Hardt, P., I. Engels, M. Rausch, M. Gajdiss, H. Ulm, P. Sass, K. Ohlsen, H.-G. Sahl, G. Bierbaum, T. Schneider, F. Grein. 2017. The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus.
    J Med Microbiol. 307(1):1-10
  • Schuster, D., J. Rickmeyer, M. Gajdiss, T. Thye, S. Lorenzen, M. Reif, M. Josten, C. Szekat, L.D.R. Melo, R.M. Schmithausen, Fl. Liégeois, H.-G. Sahl, J.-P. J. Gonzalez, M. Nagel, G. Bierbaum. 2017. Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape.
    J Med Microbiol. 307(1):57-63
  • Henrichfreise, B., M. Brunke, P. Viollier. 2016. Bacterial Surfaces: The wall that SEDS built.
    Curr Biol. 26:R1158-R1160
  • Klöckner A, M. Nagel, G. Greub, A. Sébastien, K. Hoffmann, F. Liegeois, F. Rouet, S. De Benedetti, N. Borel, B. Henrichfreise. 2016. Evidence for chlamydiae in free-living and captive great apes from central Africa.
    Emerg Infect Dis. 22: 2199-2201.
  • Kaczmarczyk, L., E. Labrie-Dion, K. Sehgal, M. Sylvester, M. Skubal, M. Josten, C. Steinhäuser, P. De Koninck, and M. Theis. 2016. New phosphospecific antibody reveals isoform-specific phosphorylation of CPEB3 protein.
    PLoS One 11(2):e0150000
  • A Elnakady, Y., I. Chatterjee, M. Bischoff, M. Rohde, M. Josten, H.-G. Sahl, M. Herrmann, and R. Müller. 2016. Investigations to the antibacterial mechanism of action of Kendomycin.
    PLoS One 11(1):e0146165
  • Müller, A., M. Wenzel, H. Strahl, F. Grein, T.N. Saaki, B. Kohl, T. Siersma, J.E. Bandow, H.-G. Sahl, T. Schneider, L.W. Hamoen. 2016. Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.precursors.
    PNAS. Epub ahead of print
  • Klöckner, A., H. Bühl, P. Viollier, B. Henrichfreise. 2016. Deconstructing the chlamydial cell wall.
    Curr Top Microbiol Immunol. Epub ahead of print
  • Barac, P., H. Harms, I. Engels, S. Kehraus, T. Schneider, G.M. König. 2016. Fighting antibiotic resistance: resensitizing agents from marine derived fungi.
    Planta Med. 81(S01):S1-S381
  • Ulm, H., T. Schneider. 2016. Targeting bactoprenol-coupled cell envelope precursors.
    Appl Microbiol Biotechnol. 100(18):7815-25
  • de Gier, M.G., H.B. Albada, M. Josten, R. Willems, H. Leavis, R. van Mansveld, F. L. Paganelli, B. Dekker, J.-W.J. Lammers, H.-G. Sahl and N. Metzler-Nolte. 2016. Synergistic activity of a short lipidated antimicrobial peptide (lipoAMP) and colistin or tobramycin against Pseudomonas aeruginosa from cystic fibrosis patients.
    MedChem Comm. 7:148-156
  • Homma, T, A. Nuxoll, A.B. Gandt, P. Ebner, I. Engels, T. Schneider, F. Götz, K. Lewis, B.P. Conlon. 2016. Dual targeting of cell wall precursors by Teixobactin leads to cell lysis.
    Antimicrob Agents Chemother. 60(11):6510-6517
  • Mann, P.A., A. Müller, K.A. Wolff, T. Fischmann, H. Wang, P. Reed, Y. Hou, W. Li, C.E. Müller, J. Xiao, N. Murgolo, X. Sher, T. Mayhood, P.R. Sheth, A. Mirza, M. Labroli, L. Xiao, M. McCoy, C.J. Gill, M.G. Pinho, T. Schneider, T. Roemer. 2016. Chemical genetic analysis and functional characterization of staphylococcal wall teichoic acid 2-epimerases reveals unconventional antibiotic drug targets.
    PLoS Pathog. 12(5):e1005585
  • Henrich, E., Y. Ma, I. Engels, D. Münch, C. Otten, T. Schneider, B. Henrichfreise, H.-G. Sahl, V. Dötsch, F. Bernhard. 2016. Lipid Requirements for the Enzymatic Activity of MraY Translocases and in vitro Reconstitution of Lipid II Synthesis Pathway.
    J Biol Chem. 291(5):2535-46
  • Scherer, K.M., J.H. Spille, H.-G. Sahl, F. Grein, and U. Kubitscheck. 2015. The lantibiotic nisin induces lipid II aggregation, causing membrane instability and vesicle budding.
    Biophys J. 108(5):1114-24
  • Ling, L.L., T. Schneider, A.J. Peoples, A. L. Spoering, I. Engels, B.P. Conlon, A. Mueller, T.F. Schäberle, D.E. Hughes, S. Epstein, M. Jones, L. Lazarides, V.A. Steadman, D.R. Cohen, C.R. Felix, K.A. Fetterman, W.P. Millett, A.G. Nitti, A.M. Zullo, C. Chen, and K.Lewis. 2015. A new antibiotic kills pathogens without detectable resistance.
    Nature. 517(7535):455-9
  • Münch, A., I. Engels, A. Müller, K. Reder-Christ, H. Falkenstein-Paul, G. Bierbaum, F. Grein, G. Bendas, H.-G. Sahl, and T. Schneider. 2015. Structural variations of the cell wall precursor lipid II - Influence on binding and activity of the lipoglycopeptide antibiotic oritavancin.
    Antimicrob Agents Chemother. 59(2):772-81
  • Otten, C., S. De Benedetti, A. Gaballah, H. Bühl, A. Klöckner, J. Brauner, H.-G. Sahl, and B. Henrichfreise. 2015. Co-solvents as stabilizing agents during heterologous overexpression in Escherichia coli – application to chlamydial penicillin-binding protein 6.
    PLoS One. 10(4):e0122110

 

 

2010 - 2014

 

  • Essig, A., D. Hofmann, D. Münch, S. Gayathri, M. Künzler, P.T. Kallio, H.-G. Sahl, G. Wider, T. Schneider, and M. Aebi. 2014. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis.
    J Biol Chem. 289(50):34953-64

  • Li, W., H. Ulm, M. Rausch, Li X, K. O´Riordan, J.C. Lee, T. Schneider, and C.E. Müller. 2014. Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: Characterization of the  UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.
    Int J Med Microbiol. 304(8):958-69
  • Münch, D., A. Müller, T. Schneider, B. Kohl, M. Wenzel, J.E. Bandow, S. Maffioli, M. Sosio, S. Donadio, R. Wimmer, and H.G. Sahl. 2014.The lantibiotic NAI-107 binds to bactoprenol bound cell wall precursors and impairs membrane functions.
    J Biol Chem. 289(17):12063-76
  • Klöckner, A., C. Otten, A. Derouaux, W. Vollmer, H. Bühl, S. DeBenedetti, D. Münch, M. Josten, K. Mölleken, H.-G. Sahl, and B. Henrichfreise. 2014. AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae isolates.
    Nat Commun. 5:4201
  • De Benedetti, S., H. Bühl, A. Gaballah, A. Klöckner, C. Otten, T. Schneider, H.-G. Sahl, and B. Henrichfreise. 2014. Characterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae. 
    Front Cell Infect Microbiol. 4:19
  • Schneider, T., A. Müller, H. Miess, and H. Gross. 2014. Cyclic lipopeptides as antibacterial agents - Potent antibiotic activity mediated by intriguing mode of action.  

    Int J Med Microbiol. 304(1):37-43

  • Mann, P.A., A. Müller, L. Xiao, P.M. Pereira, C. Yang, S. Ho Lee, H. Wang, J. Trzeciak, J. Schneeweis, M.M. Dos Santos, N. Murgolo, X. She, C. Gill, C.J. Balibar, M. Labroli, J. Su, A. Flattery, B. Sherborne, R. Maier, C.M. Tan, T. Black, K. Onder, S. Kargman, F.J. Jr. Monsma, M.G. Pinho, T. Schneider,  and T. Roemer. 2013.  Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme.
    ACS Chem Biol. 8(11):2442-2451
  • Roemer, T., T. Schneider, and M.G. Pinho. 2013. Auxiliary factors: a chink in the armor of MRSA resistance to ß-lactam antibiotics.
    Curr Opin Microbiol. 16(5):538-548
  • Vollmer, J., A. Schiefer, T. Schneider, K. Jülicher, K.L. Johnston, M.J. Taylor, H.-G. Sahl, A. Hoerauf, and K. Pfarr. 2013. Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes.
    Int J Med Microbiol. 303(3):140-149
  • Quiblier, C., A. Luczak-Kadlubowska, E. Holdener, D. Alborn, T. Schneider, I. Wiedemann, M.G. Pinho, H.-G. Sahl, S. Rohrer, B. Berger-Bächi, and M.M. Senn. 2013. The Staphylococcus aureus membrane protein SA2056 interacts with peptidoglycan synthesis enzymes. 
    Antibiotics 2:11-27
  • Bayer, A.S., T. Schneider, and H.-G. Sahl. 2013. Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall.
    Ann N Y Acad Sci. 1277(1):139-58

  • Koyama, N., Y. Tokura, D. Münch, H.-G. Sahl, T. Schneider, Y. Shibagaki, H. Ikeda, and H. Tomoda. 2012. The nonantibiotic small molecule cyslabdan enhances the potency of ß-lactams against MRSA by inhibiting pentaglycine interpeptide bridge synthesis.
    PLoS One. 7(11):e48981
  • Oeemig, J.S., C. Lynggaard, D.H. Knudsen, F.T. Hansen, K.D. Noergaard, T. Schneider, B.S. Vad, D. Sandvang, L.A. Nielsen, S. Neve, H.H. Kristensen, H.-G. Sahl, D.E. Otzen, and R. Wimmer. 2012. Eurocin, a new fungal defensin: structure, lipid binding and its mode of action.
    J Biol Chem. 287(50):42361-72
  • Roos, C., M. Zocher, D. Müller, D. Münch, T. Schneider, H.-G. Sahl, F. Scholz, J. Wachtveitl, Y. Ma, D. Proverbio, E. Henrich, V. Dötsch, and F. Bernhard. 2012.
    Biochim Biophys Acta. 1818(12):3098-3106
  • Müller, A., D. Münch, Y. Schmidt, K. Reder-Christ, G. Schiffer, G. Bendas, H. Gross, H.-G. Sahl, T. Schneider, H. Brötz-Oesterhelt. 2012. The lipodepsipeptide empedopeptin inhibits cell wall biosynthesis through Ca2+-dependent complex formation with peptidoglycan precursors.
    J Biol Chem. 287(24):20270-20280
  • Müller, A., H. Ulm, K. Reder-Christ, H.-G. Sahl, T. Schneider. 2012. Interaction of type A lantibiotics with undecaprenol-bound cell envelope precursors.
    Microb Drug Resist. 18(3): 261-270
  • Münch, D., T. Roemer, S.H. Lee, M. Engeser, H.-G. Sahl, T. Schneider. 2012. Identification and in vitro analysis of the GatD/MurT enzyme-complex catalyzing lipid II amidation in Staphylococcus aureus.
    PLoS Pathog. 8(1): e1002509
  • Ma, Y., D. Münch, T. Schneider, H.-G. Sahl, A. Bouhss, U. Ghoshdastider, J. Wang, V. Dötsch, X. Wang, and F. Bernhard. 2011. Preparative scale cell-free production and quality optimization of MraY homologues in different expression modes.
    J Biol Chem. 286(45): 38844-38853
  • Gaballah, A., A. Kloeckner, C. Otten, H.-G. Sahl, and B. Henrichfreise. 2011. Functional analysis of the cytoskeleton protein MreB from Chlamydophila pneumoniae.
    PLoS One. 6(10): e25129
  • Schneider, T., T. Kruse, R. Wimmer, I. Wiedemann, V. Sass, U. Pag, A. Jansen, A.K. Nielsen, P.H. Mygind, D.S. Raventós, S. Neve, B. Ravn, A.M.J.J. Bonvin, L. De Maria, A.S. Andersen, L.K. Gammelgaard, H.-G. Sahl, and H-H. Kristensen. 2010. Plectasin, a fungal defensin, targets the bacterial cell wall precursor lipidII.
    Science 328:1168-1172
  • Sass, V., T. Schneider, M. Wilmes, C. Körner, A. Tossi, N. Novikova, O. Shamova, and H.-G. Sahl. 2010. Human beta-defensin 3 inhibits cell wall biosynthesis in staphylococci.
    Infect Immun. 78:2793-80
  • Schneider, T. and H.-G. Sahl. 2010. Lipid II and other bactoprenol-bound cell wall precursors as drug targets.
    Curr Opin Investig Drugs. 11:157-164
  • Schneider, T. and H.-G. Sahl. 2010. An oldie but a goodie – cell wall biosynthesis as an antibiotic target pathway.
    Int J Med Microbiol. 300:161-169

 

 

2005 - 2009

 

  • Henrichfreise, B., A. Schiefer, T. Schneider, E. Nzukou, C. Poellinger, T.-J. Hoffmann, K. L. Johnston, K. Moelleken, I. Wiedemann, K. Pfarr, A. Hoerauf, and H.-G. Sahl. 2009. Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?
    Mol Microbiol. 73:913-923
  • Böttiger, T., T. Schneider, B. Martínez, H.-G. Sahl, I. Wiedemann. 2009. The influence of Ca2+ ions on the activity of lantibiotics containing a mersacidin-like lipid II binding motif.
    Appl Environ. Microbiol. 75:4427-4434
  • Schneider, T., K. Gries, M. Josten, I. Wiedemann, S. Pelzer, H. Labischinski and H.-G. Sahl. 2009. The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol-phosphate.
    Antimicrob Agents Chemother. 53:1610-1618
  • Martínez, B., T. Böttiger, T. Schneider, A. Rodríguez, H.-G. Sahl, and I. Wiedemann. 2008. The unmodified bacteriocin lactococcin 972 specifically interacts with the cell wall precursor lipid II.
    Appl Environ Microbiol. 74:4666-4670 
  • Henrichfreise, B., I. Wiegand, I. Luhmer-Becker, and B. Wiedemann. 2007. Development of resistance in wild-type and hypermutable Pseudomonas aeruginosa strains exposed to clinical pharmacokinetic profiles of meropenem and ceftazidime simulated in vitro.
    Antimicrob Agents Chemother. 51:3642-3649.
  • Henrichfreise, B., I. Wiegand, W. Pfister, and B. Wiedemann. 2007. Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation.
    Antimicrob Agents Chemother. 51:4062-4070.
  • Wiedemann, I., T. Böttiger, R.R. Bonelli, T. Schneider, H.-G. Sahl, and B. Martinez. 2006. Lipid II-based antimicrobial activity of the lantibiotic plantaricinC.
    Appl Environ Microbiol 72:2809-2814.
  • Bonelli, R.R., T. Schneider, H.-G. Sahl, and I. Wiedemann. 2006. Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies.
    Antimicrob Agents Chemother. 50:1449-1457. 
  • Henrichfreise, B., I. Wiegand, J. Wagner, and Wiedemann B. 2006. VIM-Metallo-Beta-Lactamase bei Pseudomonas aeruginosa.
    Chemotherapie Journal 1:17-19.
  • Henrichfreise B, I. Wiegand, K.J. Sherwood, and B. Wiedemann. 2005. Detection of VIM-2 metallo-beta-lactamase in Pseudomonas aeruginosa from Germany.
    Antimicrob Agents Chemother. 49:1668-1669.
  • Schneider, T., M.M. Senn, B. Berger-Bächi, A. Tossi, H.-G. Sahl, and I. Wiedemann. 2004. In vitro assembly of the complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus.
    Mol Microbiol. 53:675-685.

 

 

2002 - 2004

 

  • Kresken, M., B. Henrichfreise, S. Bagel, J. Brauers, B. Wiedemann. 2004. High prevalence of the ermB gene among erythromycin-resistant streptococcus pneumoniae isolates in Germany during the winter of 2000-2001 and in vitro activity of telithromycin.
    Antimicrob Agents Chemother. 48:3193-3195.
  • Hoffmann, A., T. Schneider, U. Pag, and H.-G. Sahl. 2004. Localisation and functional analysis of PepI, the immunity peptide of the Pep5 producing Staphylococcus epidermidis 5.
    Appl Environ Microbiol. 70:3263-3271.
  • Staubitz, P., H. Neumann, T. Schneider, I. Wiedemann, and A. Peschel. 2004. MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.
    FEMS Microbiol Lett. 231: 67-71.
  • Stock, I., B. Henrichfreise, B. Wiedemann. 2002. Natural antibiotic susceptibility and biochemical profiles of Yersinia enterocolitica-like strains: Y. bercovieri, Y. mollaretii, Y. aldovae and 'Y. ruckeri'.
    J Med Microbiol. 51:56-69.


 



 

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